Table 1.
Baseline characteristics of thyroid cancer and control group.
Table 2.
Quartiles of Plasma metal.
Fig 1.
Spearman correlation analysis of Plasma metals.
Fig 2.
Positive WQS weight distribution map.
Fig 3.
Negative WQS weight distribution map.
Fig 4.
BKMR analysis of metal mixture effects on thyroid cancer risk.
a. Cumulative effect of metal mixture; b. Single metal combined effect; c. Single variable exposure-response function for each metal; d. Bivariate exposure-response function associated with mixed metal exposure and thyroid cancer.
Fig 5.
Forest diagram of the relationship between metal-to-metal interactions and thyroid cancer.
* P < 0.05, ** P < 0.01, and *** P < 0.001.
Fig 6.
Pathway analysis of the mediating effect of metals on the risk of thyroid cancer.
a. Analysis of the mediating effect pathway between Sn and thyroid cancer; b. Analysis of the mediating effect pathway between Cd and thyroid cancer; c. Analysis of the mediating effect pathway between Ni and thyroid cancer; d. Analysis of the mediating effect pathway betweenAs and thyroid cancer. Notes: ACME, average causal mediation effects (indirect effect); ADE, average direct effects. * P < 0.05, ** P < 0.01, and *** P < 0.001.