Fig 1.
Mean (± standard deviation) serum cortisol concentrations of 3 healthy dogs at times 0, 1.5, 3, 4, 5, and 6 hours following intravenous administration of butorphanol (0.3 mg/kg) at time 0. Return to baseline was defined as a cortisol concentration within 30% of the original value.
Fig 2.
Serum cortisol concentrations at various time points following treatments.
Box and whisker plot illustrating the mean serum cortisol concentrations (µg/dL) for 11 healthy Beagles at baseline (T0), 6 hours following treatment (T6; saline 0.5 mL IV, butorphanol 0.3 mg/kg IV, and combination butorphanol 0.3 mg/kg IV and dexmedetomidine 5 µg/kg IV) and 1 hour post cosyntropin (T7; 5 µg/kg IV). There was no statistically significant difference between T0 and T6 in any treatment group (p = 0.29) or between T7 (p = 0.84). Bars represent standard deviation.