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Fig 1.

Schematic of study design.

Abbreviations: CPPE: Complicated parapneumonic effusion, IET: Intrapleural enzyme therapy (tPA/DNase), NS: Normal saline, CXR: Chest X-ray, US: Ultrasound, CT scan: Computed Tomography scan. *Chest drain blockage is assessed by lack of tidaling, lack of fluid drainage, and presence of pleural fluid on US exam.

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Fig 1 Expand

Table 1.

Patient categories based on chest tube and treatment status organized into ordinal levels in a multistate modeling framework.

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Table 1 Expand

Fig 2.

Study events and activities.

*If a chest CT scan is available, there is no need for chest X-ray. ** Starting immediately upon randomization, or if recently flushed, 6 ± 2 hours after the chest drain was flushed.

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Fig 2 Expand

Table 2.

Imaging data collected on day of chest drain removal.

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Table 2 Expand