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Fig 1.

CONSORT flow diagram.

mITT: modified intention-to-treat; PP: per protocol.

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Fig 2.

Timeline of SEEGEN phase II.

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Fig 3.

Structural model multilevel intervention.

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Table 1.

Participant characteristics.

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Table 2.

Primary and secondary outcomes at T2 and change between T0-T2.

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Table 3.

Primary and secondary outcomes estimation (ANCOVA).

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Table 3 Expand