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Fig 1.

Statistics and projections of population aging in Taiwan.

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Fig 2.

DNN-based biological age prediction architecture for different populations [9].

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Fig 3.

Biological age prediction architecture based on traditional machine learning methods [9].

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Table 1.

Comparison of related studies and this work.

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Fig 4.

Distribution of health examination years.

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Fig 5.

Age distribution of health examination participants.

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Table 2.

Sample of a single record from the merged dataset.

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Fig 6.

Features with high missing rates filtered out.

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Fig 7.

MICE flow chart [13].

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Fig 8.

MICE example [11].

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Fig 9.

Imputation process.

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Table 3.

Table of information for the filtered complete dataset.

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Fig 10.

The tree growth diagram of leaf-wise method.

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Fig 11.

Example of converting residual life to biological age.

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Table 4.

Average life expectancy by city.

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Fig 12.

Survival analysis data example [18].

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Fig 13.

Illustration of SHAP.

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Fig 14.

PCC combined with SHAP.

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Table 5.

Hardware environment table.

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Table 6.

Software environment table.

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Table 7.

Complete dataset obtained by imputation.

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Table 8.

Complete dataset obtained by filtering.

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Table 9.

Model parameters for biological age prediction with MICE imputation.

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Table 10.

Model parameters for biological age prediction with filtered dataset.

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Fig 15.

Comparison of different residual life prediction models.

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Fig 16.

Residual life prediction using the imputed dataset (Male).

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Fig 17.

Residual life prediction using the imputed dataset (Female).

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Table 11.

Residual life prediction metrics using the imputed dataset.

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Fig 18.

Residual life prediction using the filtered dataset (Male).

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Fig 19.

Residual life prediction using the filtered dataset (Female).

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Table 12.

Residual life prediction metrics using the filtered dataset.

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Fig 20.

K-M curve evaluation of biological age prediction model (Male).

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Fig 21.

K-M curve evaluation of biological age prediction model (Female).

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Table 13.

Summary of aging-related biomarkers.

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Fig 22.

PCC combined with SHAP experiment results.

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