Fig 1.
Patient selection/categorization and data collection/analysis processes are shown. Abbreviations: ARNI, angiotensin receptor-neprilysin inhibitor; BP, blood pressure; HFrEF, heart failure with reduced ejection fraction; SBP, systolic blood pressure; SNUBH, Seoul National University Bundang Hospital; SNUH, Seoul National University Hospital.
Table 1.
Baseline characteristics.
Table 2.
Factors associated with low-dose ARNI.
Fig 2.
Time-trajectories of the ARNI dose and SBP. The 1-year trajectories of the ARNI dose and SBP (from the initiation of ARNI treatment) are plotted. Solid lines represent trend lines of SBP; dotted lines represent the trend lines of ARNI dose. Shaded areas represent the confidence interval. Abbreviations: ARNI, angiotensin receptor-neprilysin inhibitor; BP, blood pressure; SBP, systolic blood pressure.
Fig 3.
Comparisons in one-year interval changes in echocardiographic features.
1-year interval changes in echocardiographic features were plotted, stratified by BP profiles. The error bars indicate interquartile ranges. Abbreviations: BP, blood pressure; E/e’, ratio of E to e’ velocity; LVEDVi, indexed left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVESVi, indexed left ventricular end-systolic volume; LVMI, left ventricular mass index.
Table 3.
Independent predictors for mortality.
Fig 4.
Comparison of clinical outcomes between dose groups according to BP profile.
Cumulative risk curves are plotted for the low-, and intermediate- to high-dose groups, among the total population, those with a high-BP profile, and those with a low-BP profile. Abbreviations: ARNI, angiotensin receptor-neprilysin inhibitor; BP, blood pressure; HF, heart failure.
Fig 5.
Outcome risk associated with low-dose ARNI treatment according to BP profile.
The risk of clinical outcomes associated with low-dose group was plotted, among the total population and in subgroups stratified by BP profile. Abbreviations: ARNI, angiotensin receptor-neprilysin inhibitor; BP, blood pressure; CI, confidence interval; CV, cardiovascular; HF, heart failure; HR, hazard ratio.