Fig 1.
Multiphysics modeling of losartan effect on tumor microenvironment.
Fig 2.
Three-dimensional breast geometry used in the simulations, showing the embedded tumor within the surrounding healthy tissue.
Fig 3.
Temporal evolution of tissue stiffness (Young’s modulus, in kPa) with and without losartan treatment a) Tumor core b) Peritumoral stroma.
Fig 4.
Stiffness distributions (kPa) at days 1, 30, and 120 of simulation. Losartan dose = 50 mg daily.
Fig 5.
Time profile of the drug concentration in tumor tissue over 24 hours after a 50 mg dose.
Fig 6.
Time profile of cancer cell concentration near tumor center (cell/cm3).
Fig 7.
Time profile of oxygen concentration (mol/m3) near the tumor center with and without losartan treatment.
Fig 8.
Spatial distribution of oxygen (mol/m³) after 120 days: (a) without treatment, (b) with losartan treatment.
Fig 9.
Time profile of porosity near the tumor center (fraction of volume that is fluid/interstitial space).