Table 1.
Demographic variables of the 25 included dogs.
Fig 1.
Concentration-time relationships for prednisolone after single oral administration in 25 dogs (data from 1 additional subject were excluded), of varying dose.
Upper panels are on linear scale (varying y-axis range), and lower panels are semilogarithmic (log10 y-axis). Filled points are the observed prednisolone concentration and open points the censored observations (below the quantification limit). The solid line represents the posterior median predicted concentration from a semiparametric (smooth) model. The light grey field represents the 90% credible interval for the predicted concentration, and the dark grey field the 50% credible interval. The estimated for each subject was obtained by integration of the posterior median concentration.
Table 2.
Parameter estimates for the allometric model for the effect of bodyweight on .
Fig 2.
Prior (purple) and posterior (green) probability distributions, for the parameters of the allometric scaling model for prednisolone apparent clearance (mL ⋅ min-1) after oral administration, as a function of bodyweight
(kg):
.
Fig 3.
Posterior-predicted area under the curve at 8 hours () by dose, for a hypothetical average dog of 5 kg, 15 kg, 30 kg or 50 kg bodyweight.
The upper panels express the dose as a function of bodyweight (mg/kg), and the lower panels express the dose as a function of body surface area (mg/m2), with body surface area defined as .