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Fig 1.

Flowchart of the proposed Margin Weighted Robust Discriminant Score (MW-RDS) algorithm.

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Table 1.

Summary of the gene expression datasets. Number of samples, number of features, and class-wise frequency distribution are shown against each dataset.

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Table 2.

Using the ID1 dataset, results of the 3 classifiers for the given feature selection methods.

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Table 3.

Using the ID2 dataset, results of the 3 classifiers for the given feature selection methods.

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Table 4.

Using the ID3 dataset, results of the 3 classifiers for the given feature selection methods.

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Table 5.

Using the ID4 dataset, results of the 3 classifiers for the given feature selection methods.

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Table 6.

Using the ID5 dataset, results of the 3 classifiers for the given feature selection methods.

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Table 7.

Using the ID6 dataset,results of the 3 classifiers for the given feature selection methods.

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Table 8.

Using the ID7 dataset, results of the 3 classifiers for the given feature selection methods.

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Table 9.

Using the ID8 dataset, results of the 3 classifiers for the given feature selection methods.

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Table 10.

Using the ID9 dataset, results of the 3 classifiers for the given feature selection methods.

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Table 11.

p-values by Wilcoson rank sum test comparing MW-RDS with feature selection methods across 9 datasets in terms classification accuracy. Statistically significance p-value (*p< 0.05, **p< ***p<0.001) indicate that MW-RDS significantly outperforms the other method.

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Fig 2.

Boxplots of classification accuracies of the 3 classifiers for the given feature selection methods on ID1.

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Fig 3.

Boxplots of sensitivies of the 3 classifiers for the given feature selection methods on ID1.

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Fig 4.

Boxplots of classification specificities of the 3 classifiers for the given feature selection methods on ID1.

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Fig 5.

Boxplots of classification F1-scores of the 3 classifiers for the given feature selection methods on ID1.

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Fig 6.

Boxplots of classification precisions of the 3 classifiers for the given feature selection methods on ID1.

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Fig 7.

Plots of classification accuracies on ID2 for various numbers of selected features.

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Fig 8.

Plots of sensitivites on ID2 for various numbers of selected features.

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Fig 9.

Plots of specificities on ID2 for various numbers of selected features.

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Fig 10.

Plots of F1-scores on ID2 for various numbers of selected features.

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Fig 11.

Plots of precisions on ID2 for various numbers of selected features.

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Fig 12.

Barplots of results on the balanced simulated dataset based on 10 selected features.

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Fig 13.

Barplots of the results on the imbalanced simulated dataset based on 10 selected features.

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Table 12.

Execution time (in miliseconds) of the feature selection methods for various number of features.

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Fig 14.

The effect of under different levels of minority amplification factor .

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Fig 15.

Classification accuracy of RF, SVM, and WKNN on 100–500 features selected by different methods for imbalanced simulated datasets.

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Fig 16.

Sensitivity of RF, SVM, and WKNN on 100–500 features selected by different methods for imbalanced simulated datasets.

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Table 13.

Classification performance (accuracy, sensitivity, specificity, F1-score, and precision) based on 50 selected features, reported as over 500 runs.

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