Fig 1.
Workflow diagram of AD precise diagnosis in this study.
Table 1.
Case Distribution in ADNI and ROSMAP Cohorts.
Table 2.
Summary of the ADNI participants.
Fig 2.
PCA distribution of Caucasian populations from ADNI and ROSMAP cohorts in the 1KGP dataset.
Fig 3.
Kernel density plots of four PRS models in CN vs. MCI group.
Fig 4.
Kernel density plots of four PRS models in MCI vs. AD group.
Fig 5.
Kernel density plots of four PRS models in CN vs. AD group.
Fig 6.
Comparison of variance explained by four PRS models.
Table 3.
Average AUC value under five-fold cross-validation for the four PRS models.
Fig 7.
PCA distribution of three comparative groups before and after data balancing.
Fig 8.
Classification performance variation with incremental methylation probes (top 50) across three comparative groups.
Fig 9.
Classification performance of top 10 methylation probe subsets in three comparative groups.
Fig 10.
Classification results of multi-omics data integration using conventional machine learning methods.
Fig 11.
Classification results of multi-omics data integration using AD-GCN model.