Fig 1.
The flowchart of the study design.
KM, Kaplan-Meier; IDI, integrated discrimination improvement; NRI, net reclassification improvement; ROC, receiver operating characteristic; CVD, cardiovascular diseases.
Fig 2.
Minimal depth variables in rank order, most important at the top.
Vertical dashed line indicates the maximal minimal depth for important variables. Indicators for nomogram A (A), nomogram B (B), nomogram C (C), nomogram D (D). SBP, systolic blood pressure; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.
Table 1.
Baseline characteristics of the training and testing sets.
Fig 3.
Nomogram A constructed using the independent prognostic factors predicting the three- and five-year CVD-free (fatal/non-fatal) survival. Q, quantile; FG, fasting glucose; SBP, systolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; SUA, serum uric acid; T2D, type 2 diabetes mellitus; BMI, body mass index; HR, heart rate.
Fig 4.
Nomogram B constructed using the independent prognostic factors predicting the three- and five-year CVD-free (fatal/non-fatal) survival. Q, quantile; FG, fasting glucose; SBP, systolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; SUA, serum uric acid; T2D, type 2 diabetes mellitus; BMI, body mass index; HR, heart rate.
Fig 5.
Nomogram C constructed using the independent prognostic factors predicting the three- and five-year CVD-free (fatal/non-fatal) survival. Q, quantile; FG, fasting glucose; SBP, systolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; SUA, serum uric acid; T2D, type 2 diabetes mellitus; BMI, body mass index; HR, heart rate.
Fig 6.
Nomogram D constructed using the independent prognostic factors predicting the three- and five-year CVD-free (fatal/non-fatal) survival. Q, quantile; FG, fasting glucose; SBP, systolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; SUA, serum uric acid; T2D, type 2 diabetes mellitus; BMI, body mass index; HR, heart rate.
Table 2.
Prediction performance of the nomogram for CVD-free survival.
Fig 7.
Time-dependent AUC curves of the nomograms for the prediction of CVD-free survival in the training set (A, B, C) and testing set (D, E, F).
Fig 8.
Calibration curves of the nomogram A.
(A) Three-year and (B) five-year CVD-free (fatal/non-fatal) survival in the training set. (C) Three-year and (D) five-year CVD-free survival in the testing set.
Fig 9.
Calibration curves of the nomogram B.
(A) Three-year and (B) five-year CVD-free (fatal/non-fatal) survival in the training set. (C) Three-year and (D) five-year CVD-free survival in the testing set.
Fig 10.
Calibration curves of the nomogram C.
(A) Three-year and (B) five-year CVD-free (fatal/non-fatal) survival in the training set. (C) Three-year and (D) five-year CVD-free survival in the testing set.
Fig 11.
Calibration curves of the nomogram D.
(A) Three-year and (B) five-year CVD-free (fatal/non-fatal) survival in the training set. (C) Three-year and (D) five-year CVD-free survival in the testing set.
Fig 12.
Decision curve analysis of CVD-free survival nomograms.
The DCA for three- (A), five-year (B), CVD-free survival prediction in training set and for three - (C) and five-year (D) CVD-free survival prediction in the testing set.
Fig 13.
Receiver operating characteristic of the nomograms for three- (A, B, C) and five-year (D, E, F) CVD-free survival prediction in the training set.
Fig 14.
Receiver operating characteristic of the nomograms for three- (A, B, C) and five-year (D, E, F) CVD-free survival prediction in the testing set.
Table 3.
Comparison of NRI and IDI among nomograms predicting three- and five-year CVD-free survival.
Fig 15.
Kaplan–Meier curves of CVD-free survival (fatal/non-fatal) for risk classification based on the nomogram A scores (A), the nomogram B scores (B), the nomogram C scores (C), and the nomogram D scores (D) in the training set. HR, hazard ratio.