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Fig 1.

Research workflow and methodology applied in this study.

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Table 1.

Comprehensive baseline characteristics and outcome of the complete dataset.

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Table 2.

Comparison between ranked features selected by ML feature selection and the FRS risk score.

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Table 2 Expand

Table 3.

The AUC of FRS and RPCE risk scores and ML models with feature selection based on a 30% validation dataset.

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Table 4.

Detailed performance metrics of ML models with feature selection.

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Table 4 Expand

Table 5.

Detailed performance metrics of best LR model (LR selected var) on the imputed dataset and complete dataset.

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Table 5 Expand

Fig 2.

SHAP Analysis.

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Fig 2 Expand

Table 6.

NRI Comparison between Machine Learning Methods and FRS.

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Table 7.

NRI Comparison between Machine Learning Methods and RPCE.

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Table 7 Expand