Table 1.
Pharmacokinetic parameters in the chemostat model.
Table 2.
Antimicrobial susceptibility of strains in this study.
Table 3.
Interaction of sulfamethoxazole/trimethoprim and rifampicin in the checkerboard assay.
Fig 1.
In vitro chemostat experiments of ST plus RFP against ST-R MRSA isolates.
ATCC29213 (A) and ATCC43300 (B) are reference strains of MSSA and MRSA, respectively. KAM444 (C) and KAM636 (D) are ST-R, and KAM1160 (E) is ST-LS MRSA isolates. The drug concentration (F) indicates the reconstruction curve from the measured data. The concentration of ST was expressed as the concentration of trimethoprim. MRSA, Methicillin-resistant Staphylococcus aureus; MSSA, Methicillin-susceptible Staphylococcus aureus ST, Sulfamethoxazole-Trimethoprim; RFP, Rifampicin; ST-resistant, ST-R.
Table 4.
MICs of surviving colonies after the in vitro pharmacodynamic model.