Fig 1.
Pelvic US example of an 8-year-old girl with P-CP.
US demonstrated (a) a vaginal width of 2.7 cm, (b) a cervix width of 1.3 cm, (c) a fundus width of 2.5 cm, (d) a uterine length of 3.5 cm, and (e) a right ovarian volume of 2.1 cc (arrows). The score for Model C was 19.4 (cutoff value > 16 for diagnosing P-CP) with a basal LH of 4.2 IU/L and estradiol of 60.8 pg/mL. US, ultrasound; P-CP, progressive central precocious puberty; LH, luteinizing hormone.
Table 1.
Baseline characteristics of the participants.
Table 2.
Univariable logistic regression analyses for P-CP.
Table 3.
Multivariable logistic regression analyses for P-CP.
Table 4.
AUCs of the each model of prediction of P-CP.
Table 5.
Comparison of the predictive performance of the P-CP with and without cervix width and fundus width.
Fig 2.
Nomogram of the Model C with pelvic US parameters.
A representation of the scoring system with nomogram for prediction of P-CP using the result of multivariable logistic regression analysis. In the representation of the scoring system using nomogram, basal LH, estradiol, and fundus width of the participant were 0.5 IU/L (6 points), 10 pg/mL (4 points), and 4 cm (14 points), respectively. According to the nomogram, the probability of P-CP was 0.91 (91%) for 24 points. US, ultrasound; LH, luteinizing hormone.
Fig 3.
Calibration plot of the Model C with pelvic US parameters.
Calibrated plots demonstrate a close approximation to the logistic calibration of each nomogram, indicating good agreement between predicted and observed outcomes when using the Model C. US, ultrasound.