Fig 1.
The diagram of experimental design and grouping.
Note: terminal deoxynucleotidyl transferase dUTP Nick End Labeling (TUNEL), High-mobility group box 1 protein(HMGB1), interleukin-6(IL-6), tumor necrosis factor-α (TNF-α), Janus kinase 2(JAK2), Signal transducer and activator of transcription 3(STAT3), phosphorylated Signal transducer and activator of transcription 3(p-STAT3), B-cell lymphoma 2(Bcl-2), Bcl-2-associated X protein(Bax) .
Fig 2.
Wet/dry weight ratio of lung tissue in each group.
Note: aP<0.05, bP<0.01 vs SHAM group, cP<0.05, dP<0.01vs. CLP group.
Fig 3.
HE staining sections and pathological scores of lung tissue(200×).
Note: aP<0.05, bP<0.01 vs SHAM group, cP<0.05, dP<0.01vs. CLP group.
Fig 4.
TUNEL fluorescence staining of lung tissue.
Note: A. Representative images for TUNEL staining in lung tissue (red: TUNEL positive cells, blue: DAPI, ×200). B.Statistical analysis results of TUNEL staining. aP<0.05, bP<0.01 vs SHAM group, cP<0.05, dP<0.01vs. CLP group.
Fig 5.
Relative expression levels of HMGB1, IL-6 and TNF-α detected via ELISA.
Note: aP<0.05, bP<0.01 vs SHAM group, cP<0.05, dP<0.01vs. CLP group.
Fig 6.
The expression of relative protein detected with western blot.
Note: aP<0.05, bP<0.01 vs SHAM group, cP<0.05, dP<0.01vs. CLP group.