Fig 1.
Overview of the study design aimed at identifying plasma and brain proteins that are causally linked to NMOSD.
Table 1.
MR results for plasma and CSF proteins markedly linked to NMOSD after FDR-adjusted.
Fig 2.
A volcano plot was created to pinpoint 4 proteins as potential targets for NMOSD from a total of (A) 734 plasma proteins and (B) 151 cerebrospinal fluid (CSF) proteins, utilizing the Wald ratio or inverse variance weighting approach.
CSF: cerebrospinal fluid, PVE: proportion of variance explained.
Fig 3.
An external validation process was performed in a forest plot to examine the causal link between 4 candidate proteins and NMOSD.
Table 2.
Sensitivity analysis on 4 potential causal proteins.
Fig 4.
Comparative analysis of MR estimates from the plasma proteome versus the brain proteome.
(A) Correlation analysis was conducted on the 67 proteins that overlapped between plasma and brain. The gray lines, both horizontal and vertical, indicate 95% confidence intervals for MR estimates. (B) The Spearman correlation coefficient was computed using various P value thresholds to incorporate MR estimates. The numbers next to the black point denote the count of overlapping proteins.
Table 3.
Druggability of proteins potentially causally associated with NMOSD.