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Table 1.

Basic characteristics of included articles.

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Fig 1.

Flow diagram of study selection.

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Fig 2.

Summary of the risk of bias.

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Table 2.

Summary of adverse reactions.

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Fig 3.

Results of Meta-analysis: (A)FEV1% pred; (B) FEV1; (C) FVC; (D) FEV1/FVC%; (E) PEFR; (F)hospital admissions; (G)exacerbation rate; (H) total symptom score; (I) adverse reactions (J)gastrointestinal adverse reactions; (K)cardiovascular adverse reactions; (L)neurological adverse reactions.

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Fig 4.

(A) Sensitivity analysis of total symptom scores; (B) Meta-analysis of total symptom scores after deleting the study of Subramanian2015.

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Fig 4 Expand

Fig 5.

Funnel plot of exacerbation rate.

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Fig 5 Expand