Fig 1.
Factors affecting mammographic texture features.
The study aims to evaluate how mammographic texture features (A) are affected by imaging parameters (F), and by genetic (B), molecular (C), cellular (D), and tissue level (E) biological factors across different scales.
Fig 2.
It starts with the recruitment of the first patient. Recruitment started on July 1st, 2024, and it is expected to end on December 15th, 2024. Participants will be followed up for 10 years. The imaging and sample collection from the resected samples starts with the first surgical intervention and ends soon after the last intervention. Imaging and biological analysis will begin after data have been obtained from the first 10 resected breasts and will continue after the imaging and sample collection have been completed. All analyses pertaining to this project are expected to be concluded by the 2-year mark after the imaging and sample collection have been finalized.
Table 1.
Inclusion and exclusion criteria.
Fig 3.
Study pipeline and data that will be acquired from the resected breasts. Each resected breast will be scanned with two mammographic imaging machines with several predefined sets of imaging parameters, yielding several images per breast sample in both raw and postprocessed formats. Next, pathological samples will be extracted from the resected breasts for further biological analyses.