Table 1.
B1, B2, B6, and B8 vitamins available commercial formulations and required oral unidose formulas.
Table 2.
Compounding formulas for 300 hard gelatin vitamin capsules.
Table 3.
HPLC stability-indicating dosing methods, general parameters.
Table 4.
Vitamin capsules treatment before HPLC-UV analysis.
Table 5.
Thiamine, riboflavine, pyridoxine and biotine method validation.
Table 6.
Thiamine chlorhydrate forced degradation.
Table 7.
Riboflavine forced degradation.
Table 8.
Pyridoxine chlorhydrate forced degradation.
Table 9.
Biotin forced degradation.
Table 10.
System Suitability Test for vitamin stability-indicating dosing methods.
Table 11.
Vitamin hard gelatin capsules, batches released and rejected since implementation.
Fig 1.
Content variation of vitamin capsules stored at ambient temperature (25 °C/ 60% RH) over time.
Fig 2.
Content variation of thiamine hydrochloride 50 mg capsules from protocol 2 stored at ambient temperature (25 °C/ 60% RH) over time.