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Table 1.

Participant characteristics.

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Table 1 Expand

Fig 1.

Plasma drug levels by group.

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Fig 1 Expand

Table 2.

Change in physiologic data over time.

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Table 2 Expand

Fig 2.

Hemodynamic and respiratory changes over time.

Data plotted as median (interquartile range) in 30-minute epochs. * Indicates significant difference in change between groups.

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Fig 2 Expand

Fig 3.

Change in energy expenditure from baseline.

Data plotted as median (interquartile range) in 30-minute epochs.

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Fig 3 Expand

Fig 4.

Change in temperature from baseline.

Data plotted as median (interquartile range) in 30-minute epochs. * Indicates significant difference in change between groups.

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Fig 4 Expand

Fig 5.

Change in energy expenditure and temperature from baseline.

Data plotted as individual median change in energy expenditure by change in temperature.

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Fig 5 Expand