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Fig 1.

Flow diagram for inclusion of participants in analysis sample.

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Table 1.

Demographic and clinical characteristics of participant sample (N, %) or median [IQR].

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Table 2.

Characterization of the six pain subgroups (“clusters”) with sickle cell disease N(%) or median [IQR].

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Table 2 Expand

Fig 2.

Panels A and B depict the relationship between clusters, or subgroups, and pain impact.

Pain impact assessed by ASCQ-Me Pain Impact Short Form (5-item questionnaire). Raw scores converted to T-scores. Higher T-scores imply better health or less pain impact. A. Plot depicting the distribution of pain impact T-scores for each cluster. B. Ordinal logistic regression modeling comparing the association of each cluster with pain impact.

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