Fig 1.
(A) Overall cardiovascular-kidney-metabolic syndrome-related Age-Adjusted Mortality Rates per 1,000,000 in Adults in the United States, 1999 to 2022, and (B) Sex-Stratified cardiovascular-kidney-metabolic syndrome-related Age-Adjusted Mortality Rates per 1,000,000 in Adults in the United States, 1999 to 2020.
* Indicates that the APC is significantly different from zero at α = 0.05. AAMR = age-adjusted mortality rate; APC = annual percent change; CI = confidence interval.
Fig 2.
Cardiovascular-kidney-metabolic syndrome-related Age-Adjusted Mortality Rates per 1,000,000, Stratified by age groups in Adults in the United States, 1999 to 2020.
* Indicates that the APC is significantly different from zero at α = 0.05. AAMR = age-adjusted mortality rate; APC = annual percent change; CI = confidence interval.
Fig 3.
Cardiovascular-kidney-metabolic syndrome-related Age-Adjusted Mortality Rates per 1,000,000, Stratified by ethnoracial groups in Adults in the United States, 1999 to 2020.
* Indicates that the APC is significantly different from zero at α = 0.05. AAMR = age-adjusted mortality rate; APC = annual percent change; CI = confidence interval.
Fig 4.
Cardiovascular-kidney-metabolic syndrome-related Age-Adjusted Mortality Rates per 1,000,000, Stratified by State in Adults in the United States, 1999 to 2020.
Fig 5.
Cardiovascular-kidney-metabolic syndrome-related Age-Adjusted Mortality Rates per 1,000,000, Stratified by Census Regions in Adults in the United States, 1999 to 2020.
* Indicates that the APC is significantly different from zero at α = 0.05. AAMR = age-adjusted mortality rate; APC = annual percent change; CI = confidence interval.
Fig 6.
Cardiovascular-kidney-metabolic syndrome-related Age-Adjusted Mortality Rates per 1,000,000 in Adults in the Metropolitan and Non-metropolitan areas in the United States, 1999 to 2020.
* Indicates that the APC is significantly different from zero at α = 0.05. AAMR = age-adjusted mortality rate; APC = annual percent change; CI = confidence interval.
Fig 7.
(A) Cardiovascular Disease and (B) type-2 Diabetes Mellitus, and (C) chronic kidney disease- related Age-Adjusted Mortality Rates per 100,000 in Adults in the United States, 1999 to 2022. * Indicates that the APC is significantly different from zero at α = 0.05. AAMR = age-adjusted mortality rate; APC = annual percent change; CI = confidence interval.
Fig 8.
Comparison of Cardiovascular-kidney-metabolic syndrome-related-related Average Age-Adjusted Mortality Rates (AAMRs) per 1,000,000 during the COVID-19 Pandemic period (2020-2022) with the pre-Pandemic period (1999-2019).