Table 1.
Clinical and laboratory characteristics of study participants.
Table 2.
Histological findings at 0-h kidney biopsy.
Fig 1.
Representative images for artery and arterioles for 0-h kidney biopsy specimens (periodic acid silver methenamine-stained).
A) Arteriosclerosis (AS) was scored as 0: no intimal thickening, 1: (b + c)/(a + d) < 50%, 2: (b + c)/(a + d) > 50%. B) Arteriolosclerosis (As) index was calculated as e/(f − e)/2. C) Arteriolar hyalinosis (AH) was scored by the percentage of hyaline thickness (red arrow) in arteriolar wall as 0: none; 1: partial; 2: < 50%; and 3: > 50%. See the “Methods” section for calculation of indices.
Table 3.
Correlations between histological score/indices at 0-h biopsy and post-donation renal function.
Fig 2.
Relationship between arteriolar hyalinosis and post-donation renal function.
A) Scatter plot shows significant correlation between post-donation serum creatinine and AH index. B) Serum creatinine levels one year after donation in participants with or without AH (AH score > 0). C) Scatter plot shows insignificant trend in relationship between changes in serum creatinine levels (ΔCr) between pre-donation and post-donation and AH index. D) ΔCr between pre-donation and post-donation in participants with or without AH. Cr, creatinine; AH, arteriolar hyalinosis evaluated in 0-h biopsy specimens.
Table 4.
Correlations between clinical parameters at baseline and histological score/indices at 0-h biopsy.
Table 5.
Multiple regression for serum uric acid (UA) and arteriolar hyalinosis (AH) index (left) and odds ratio of AH (score > 0) for 1 mg/dL increase in serum UA (right).
Fig 3.
Relationship between serum uric acid (UA) and arteriolar hyalinosis.
A) Scatter plot showing significant correlation between serum UA and AH index. B) Serum UA levels in participants with or without AH (AH index > 0). AH, arteriolar hyalinosis evaluated in 0-h biopsy specimens.
Table 6.
Correlations between clinical parameters at baseline and post-donation renal function.
Table 7.
Multiple regression analysis for serum uric acid levels at baseline and post-donation renal function.
Fig 4.
Relationship between serum uric acid (UA) and post-donation renal function.
A) Significant correlation between pre-donation serum UA and post-donation (one year after donation) serum creatinine (Cr) levels. B) Significant correlation between pre-donation UA and changes in serum creatinine (ΔCr) levels between pre-donation and post-donation.
Fig 5.
Hypothetical relationship between serum uric acid, arteriolar hyalinosis, and post-donation renal function.
UA, uric acid; Cr, creatinine; UNx, unilateral nephrectomy.