Table 1.
The demographic and clinical data of fibromyalgia patients in this study.
Table 2.
Scores of pain severity, sleep interference and rFIQ in male and female patients.
Fig 1.
Changes in average weekly pain score on a numeric rating scale and the patient’s global impression of change after intravenous lidocaine infusion.
(A) shows the percentages of patients who reported an increase, no change, or a reduction in average weekly pain score (AWP) at 3 - 6 weeks after infusion. 0 point means no change of AWP, and +1 point represents an increase in pain by 1 point after the infusion. Pain reduction is shown as −1 to −6 points, with −6 being the maximum reduction in this group. (B) shows the percentage of patients reporting various levels of change. Patient global impression of change is a 7-point single-item scale from “very much worse” to “very much improved”.
Table 3.
Characteristics of lidocaine responders in univariate analysis.
Table 4.
Comparison of scores of pain severity, sleep interference and rFIQ between non-responders and responders.
Fig 2.
Comparison of QST modalities and loss/gain phenotypes in responders and non-responders.
(A) shows the following measurement: cold and warm detection thresholds (CDT and WDT), the ability to detect temperature changes (thermal sensory limen, TSL), cold and heat pain thresholds (CPT and HPT), mechanical detection and pain thresholds (MDT and MPT), mechanical pain sensitivity (MPS), dynamic mechanical allodynia (DMA) and wind-up ratio (WUR). The data are expressed as mean ± SD. (B) shows the percentage of patients with loss or gain of function to mechanical and thermal stimuli. Loss of detection for thermal stimuli (CDT or WDT) was coded as L1, for mechanical stimuli (MDT or VDT) as L2, and loss of both as L3. Gain of function for thermal stimuli (CPT or HPT) was coded as G1, for mechanical stimuli (MPT, MPS, DMA and WUR) as G2, and gain for both as G3. L0 represented no loss for thermal or mechanical detection and G0 meant no thermal or mechanical allodynia or hyperalgesia.