Fig 1.
Study design flowchart.
Table 1.
MR results for plasma and CSF proteins after Bonferroni correction.
Fig 2.
Forest map of reverse causality detection about significant protein.
Table 2.
Drug targets analysis.
Fig 3.
Network pharmacology analysis.
(A) Drug-disease target Venn diagram; (B) Drug-Disease-Target network. The red color indicates SLE; The blue color indicates the drugs; the yellow color indicates the targets; (C) PPI network of shared targets of Voclosporin and Cyclosporine in treatment of SLE; (D) Core targets of overlapping targets.
Fig 4.
Molecular docking diagrams of SLE related targets with main compounds of Voclosporin and Cyclosporine.
Table 3.
Docking simulation for active molecular and targets of SLE.