Fig 1.
The Scania aTBS implementation study (SATIS) trial profile.
rTMS repetitive Transcranial Magnetic Stimulation, ECT Electroconvulsive Therapy, MRI Magnetic Resonance Imaging. a Wanted therapy instead, wanted ECT instead, unable to come to the clinic because of agoraphobia, did not want to participate, unable to travel to Helsingborg for treatment, got diagnosed with autism the day before and needed time to adjust, unable to attend treatment until early 2022, did not want to stop medication with benzodiazepines and antiepileptics. b Sibling with epilepsy, suspected epileptic seizure requiring electroencephalogram before treatment which was not possible to obtain prior to end of inclusion period. c Dorsal column stimulator from 2002.
Table 1.
Demographic information and treatment history for all participants (N = 20) in the Scania aTBS implementation study (SATIS) at inclusion.
ECT Electroconvulsive therapy, rTMS repetitive transcranial magnetic stimulation, MADRS Montgomery Åsberg Depression Rating Scale, EQ-5D EuroQol-5 Dimension, VAS Visual Analogue Scale, CGI Clinical Global Impression.
Table 2.
A comparison between different rTMS protocols.
HF-rTMS high-frequency repetitive transcranial magnetic stimulation, iTBS intermittent theta burst stimulation, SAINT Stanford Accelerated Intelligent Neuromodulation Therapy, SATIS Scania aTBS implementation study.
Fig 2.
Top: Individual Montgomery-Åsberg Depression Rating Scale (MADRS) scores in the PP-group.
Red line represents mean MADRS scores at all measured time-points (screening, 0 = baseline, 1 = after the first day of treatment, 3 = after the third day of treatment, 5 = after all treatments, 35 = at the 30-day follow-up). The three patients with the highest score (38,39 and 42) after day 5, all received ECT during the 30-day follow-up period. Two of those achieved lasting remission and one only met response criteria at follow-up. This patient had MADRS 12 after completing 5 ECT sessions but worsened some until follow-up. Bottom: Individual Montgomery-Åsberg Depression Rating Scale Self-assessment (MADRS-S) scores in the PP-group. Red line represents mean MADRS-S scores at all measured time-points (screening, 0 = baseline, 1 = after the first day of treatment, 2 = after the second day of treatment, 3 = after the third day of treatment, 4 = after the fourth day of treatment, 5 = after all treatments, 35 = at the 30-day follow-up).
Fig 3.
CGI-I after the last day of treatment (left) and at the 30 day follow-up (right) in the PP-group (n = 18). CGI-I Clinical Global Impression—Improvement. No patients were rated “much worse” or “very much worse”. Three patients received ECT between the last day of treatment and the 30-day follow-up.
Table 3.
Content analysis of pre-study nurse-interviews organized in categories, subcategories and examples of codes, representing relevant opinions expressed.
Table 4.
Content analysis of post-study nurse-interviews organized in categories, subcategories and examples of codes, representing relevant opinions expressed.