Table 1.
Randomization reporting and risk of bias for included randomized trials.
Fig 1.
Forest plot of mean differences for baseline age for included trials.
The NINDS rt-PA Stroke Study (NINDS) is the only included study for which the 95% confidence interval did not include the null.
Fig 2.
Forest plot of mean differences for baseline weight for included trials.
The NINDS rt-PA Stroke Study was the only included study for which the 95% confidence interval did not include the null.
Fig 3.
Forest plot of mean difference for baseline NIHSS for included trials.
The ECASS-3 RCT was the only included study for which the 95% confidence interval did not include the null.
Fig 4.
Pooled absolute risk difference for all included trials.
Fig 5.
The pooled effect of treatment with and without the NINDS rt-PA Stroke Study and ECASS-3 RCT.
Table 2.
Recommendations for improved randomization reporting in randomized controlled trials. Adapted from Berger and Cristophi [32].