Fig 1.
Summary of the koala groups recruited for this study.
Table 1.
Two-by-two table for calculating the sensitivity, specificity, NPV and PPV.
Fig 2.
Box and whiskers plot of KYN, TRP, and KYN:TRP ratio in clinically normal (n = 35), diseased (n = 35) and ‘other’ koalas (n = 10).
(A) KYN concentrations. (B) TRP concentrations. (C) KYN:TRP ratio. The outlier in the diseased group had both eyes and UGT clinical signs with mammary mass, and the outlier in the ‘other’ group had leukaemia. * = statistically significant.
Table 2.
Summary of the median and range of TRP, KYN, and the KYN:TRP ratios in clinically normal, diseased, and ‘other’ koalas.
Table 3.
Sensitivity, specificity, and predictive values of the proposed KYN, TRP, and KYN:TRP ratio references ranges for screening diseased koalas.
Table 4.
Optimal cut-off points and its sensitivity, specificity, and predictive values of the proposed KYN, TRP, and KYN:TRP ratio in clinically normal versus diseased/‘other’, and released/recovered versus euthanised in diseased/‘other’ koalas.