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Fig 1.

Flow diagram of study.

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Fig 2.

Forest plot for mean shock index based on total population.

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Table 1.

Summary of included studies reporting shock index, age shock index, modified shock index and age modified shock index and acute heart failure clinical outcomes.

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Table 2.

Heterogeneity results of included studies according to shock index, age shock index, and modified shock index.

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Fig 3.

Forest plot for mean shock index based on studies reported in-hospital mortality.

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Fig 4.

Forest plot for mean shock index based on studies reported follow-up mortality.

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Fig 5.

Forest plot for mean shock index based on studies reported death/survival groups.

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Fig 6.

Forest plot for standard shock index mean difference based on studies reported death/survival groups.

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Fig 7.

Forest plot for shock index (as bivariate variable) odds ratio on in-hospital mortality.

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Table 3.

Summary of shock index cut-off characteristics.

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Fig 8.

Plots showing the Youden index (A), the calculated ROC (B) and SROC (C) curves of the included studies reporting SI cut-off points for predicting in-hospital mortality. The optimal SI cut-off is indicated by the “+” symbol.

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Fig 9.

Forest plot for mean age shock index based on studies reported mortality (in-hospital and follow-up mortality).

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Fig 10.

Forest plot for mean age shock index based on studies reported death/survival groups.

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Fig 11.

Forest plot for standard age shock index mean difference based on studies reported death/survival groups.

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Fig 12.

Forest plot for age shock index (as bivariate variable) odds ratio on in-hospital mortality.

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Fig 13.

Plots showing the Youden index (A), the calculated ROC (B) and SROC (C) curves of the included studies reporting ASI cut-off points for predicting in-hospital mortality. The optimal ASI cut-off is indicated by the “+” symbol.

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Fig 14.

Forest plot for mean modified shock index based on studies reported mortality (in-hospital and follow-up mortality).

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Fig 15.

Forest plot for mean modified shock index based on studies reported death/survival groups.

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Fig 16.

Forest plot for standard modified shock index mean difference based on studies reported death/survival groups.

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Fig 17.

Summary of acute heart failure prognostic assessment markers.

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