Fig 1.
Study subject inclusion and exclusion flowchart, NHANES 2007–2018.
Table 1.
Baseline characteristics of patients according to SII tertile.
Table 2.
Baseline characteristics of patients according to PIV tertile.
Table 3.
Multivariate adjusted Cox models for SII and all-cause mortality.
Table 4.
Multivariate adjusted Cox models for PIV and all-cause mortality.
Fig 2.
KM models for SII and PIV with all-cause and cardiovascular mortality in patients with FLD, NHANES 2007–2018.
A: KM plot (all-cause) for SII; B: KM plot (all-cause) for SIRI; C: KM plot (CVD-cause) for SII; D: KM plot (CVD-cause) for PIV. The horizontal axis of the KM plot represents survival time (months) and the vertical axis represents the corresponding (all-cause or CVD) survival probability. The log-rank test was used to analyze differences between groups.The low (T1), middle (T2), and high (T3) tertiles of the SII/PIV were indicated using red, green, and blue solid lines, respectively. Abbreviations: KM, Kaplan-Meier; FLD, fatty liver disease; CVD, cardiovascular disease.
Fig 3.
RCS models of SII (A) and PIV (B) with all-cause mortality in patients with FLD, NHANES 2007–2018. The horizontal axis of the RCS plot represents the level of SII/PIV, and the vertical axis represents the log hazard value for all-cause mortality. In Panel A, the point where the two dashed lines cross is the turning point (458.71). In panel A, the p non-linear of 0.0032 represented the presence of a non-linear association between SII and all-cause mortality in patients with FLD, while in panel B, the p non-linear was 0.2744, suggesting a linear correlation. Abbreviations: RCS, restricted cubic splines; FLD, fatty liver disease.
Fig 4.
Subgroup analysis of SII (A) and PIV (B) with all-cause mortality in patients with FLD, NHANES 2007–2018. In subgroup analyses, “Characteristics” represented the different subgroups included, “Total (N)” represented the number of participants in each subgroup, “HR” represented the effect value of the association in each subgroup (hazard ratio), “Adjusted P value” represented the significance of the associations in the subgroups, and “P for interaction” represented whether the associations were significantly different between the subgroups. Abbreviations: BMI, body mass index; PIR, family income-to-poverty ratio; ALT, alanine transaminase; T1, T2, T3 = tertile1, tertile2, tertile3.