Fig 1.
Abbreviations: AKI = Acute Kidney Injury; AKI 1 = Kidney Disease: Improving Global Outcome (KDIGO) Stage 1 AKI; AKI 2 = KDIGO Stage 2 AKI; AKI 3 = KDIGO Stage 3 AKI; MGI = Michigan Genomics Initiative; RRT = Renal Replacement Therapy; S-AKI = Sepsis-associated Acute Kidney Injury; SCr = Serum Creatinine; Sepsis-3 = The Third International Consensus Definitions for Sepsis and Septic Shock.
Table 1.
Characteristics of full cohort and univariate analyses of patients developing AKI (cases) versus those without AKI (controls).
Fig 2.
Manhattan plots for GWAS model.
2A. Model 1. 2B. Model 2. 2C. Model 3. (•) Genome Wide Significance Threshold (P<5x10-8) red dashed line. (•) Suggestive/Replicative Significance Threshold (P<1x10-6) blue dashed line.
Fig 3.
Overlap and Intersection of suggestive variants from the three genome-wide association studies.
Gene Names: ARL4C = ADP Ribosylation Factor like GTPase 4C; CHRNA7 = Cholinergic Receptor Nicotinic Alpha 7 Subunit; IQCJ = IQ Domain-Containing Protein J; KCNMB2 = Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 2; NDFIP1 = Nedd4 Family Interacting Protein 1; SCHIP1 = Schwannomin Interacting Protein 1; SLAMF6 = SLAM Family Member 6; TRIB2 = Tribbles Pseudokinase 2.
Table 2.
Genome Wide Association Study (GWAS) results: P < 1 x 10−6, minor allele frequency > 1%.