Fig 1.
A synopsis of the research design and flowchart.
Fig 2.
PPI network of all text mining genes (TMG) related to ChAc.
Table 1.
Top 15 biological process concepts from GO that are enriched and linked to the TMGs.
Table 2.
Top 10 enriched KEGG pathways assigned to the TMGs.
Fig 3.
Identification and enrichment analysis of the TMGs.
(A) PPI network of the 26 target TMGs as visualized by Cytoscape. (B, C) Using MCODE, the two modules were retreived from the PPI network, namely, Module 1 and Module 2. Both the modules were having 3 nodes each.
Fig 4.
Gene Ontology terms of the 6 hub genes.
The enriched GO keywords associated with the nervous system and protein localization are depicted in the image. We used DAVID and the REVIGO web server to perform route and functional enrichment analysis.
Fig 5.
Gene Ontology (GO) terms in the two modules.
(A) Module-1’s significantly enriched GO keywords. (B) Module-2’s significantly richer GO keywords. A tree depiction made with the ShinyGo web server showed a strong correlation (P > 0.005) between the functional and route enrichment studies in ChAc.
Table 3.
Hub node genes in the PPI network identified with a filtering node degree = 2.
Table 4.
Information on the 23 Food and Drug Administration (FDA)-approved drugs that likely target three of the six hub genes.
Fig 6.
Functional examination of the 6 key significant genes found in modules 1 and 2.
(A) ClueGO was used to visualize the main gene’s pathways and functions. (B) The distribution of the core gene’s pathways and functions.