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Table 1.

Hearing test distribution in three experimental conditions.

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Table 2.

Sound levels associated with the MRI acquisition sequences used by the Courtois NeuroMod project.

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Fig 1.

Pure-tone audiometric threshold differences (in dB HL), post-scan minus pre-scan, as a function of the pure-tone frequency.

a) presents a schematic description of the test session progress. Results are presented for b) anatomical scans and c) functional scans, as these sequences do not generate similar noises in terms of both amplitude and frequency spectrum. Pure-tone threshold results are presented for both standard (0.25, 0.5, 1, 2, 3, 4, 6 and 8 kHz) and extended high frequency (9, 10, 11.2, 12.5, 14, 16, 18, and 20 kHz) ranges. For each participant, graphs on the top row are for the left ear, while graphs on the bottom row are for the right ear. Worsening hearing thresholds of a mild degree (> 5 but < 20 dB HL) are highlighted with an orange background, while severe increases (≥ 20 dB HL) are highlighted with a red background. When multiple observations have been conducted per participant, each line represents a different observation. Missing values in the graph indicate that the participant did not give any behavioral response at that frequency pre- and/or post-scan. Original images in panel a) were adapted from vectorportal.com (MRI scanner; CC BY 4.0 license), svgrepo.com (headphones; CC0 license), and commons.wikimedia.org (sinus wave; released into the public domain by Mikael Häggström).

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Fig 2.

DPOAE differences (in dB SPL), post-scan minus pre-scan, as a function of the F2 frequency.

a) presents a schematic description of the test session progress. Results are presented for b) anatomical scans and c) functional scans. DPOAE amplitudes are presented for F2 = 1, 1.5, 2, 3, 4, 6, 8 and 10 kHz. For each participant, graphs on the top row are for the left ear, while graphs on the bottom row are for the right ear. Significant amplitude decreases [49] are highlighted with a red background. When multiple observations have been conducted per participant, each line represents a different observation. Missing values in the graph indicate that the participant’s DPOAE amplitude did not exceed the established noise floor threshold (see Methods, Otoacoustic emissions section) for that F2 frequency pre- and/or post-scan. Original images in panel a) were adapted from vectorportal.com (MRI scanner; CC BY 4.0 license), svgrepo.com (earphones; CC0 license), and freesvg.org (ear; public domain).

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Fig 3.

Pure-tone audiometric threshold differences (in dB HL), delayed observation minus baseline, as a function of the pure-tone frequency.

a) presents a schematic description of the test session progress. Results are presented for b) anatomical scans and c) functional scans. Pure-tone threshold results are presented for both standard (0.25, 0.5, 1, 2, 3, 4, 6 and 8 kHz) and extended high frequency (9, 10, 11.2, 12.5, 14, 16, 18, and 20 kHz) ranges. For each participant, graphs on the top row are for the left ear, while graphs on the bottom row are for the right ear. When multiple observations have been conducted per participant, each line represents a different observation. Worsening hearing thresholds of a mild degree (> 5 but < 20 dB HL) are highlighted with an orange background, while severe increases (≥ 20 dB HL) are highlighted with a red background. Missing values in the graph indicate that the participant did not give any behavioral response at that frequency during the delayed observation and/or the baseline. Original images in panel a) were adapted from vectorportal.com (MRI scanner; CC BY 4.0 license), svgrepo.com (headphones; CC0 license), and commons.wikimedia.org (sinus wave; released into the public domain by Mikael Häggström).

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Fig 3 Expand

Fig 4.

DPOAE differences (in dB SPL), delayed observation minus baseline, as a function of the F2 frequency.

a) presents a schematic description of the test session progress. Results are presented for b) anatomical scans and c) functional scans. DPOAE amplitudes are presented for F2 = 1, 1.5, 2, 3, 4, 6, 8 and 10 kHz. For each participant, graphs on the top row are for the left ear, while graphs on the bottom row are for the right ear. Significant amplitude decreases [49] are highlighted with a red background. When multiple observations have been conducted per participant, each line represents a different observation. Missing values in the graph indicate that the participant’s OAE response did not exceed the established noise floor threshold (see Methods, Otoacoustic emissions section) for that F2 frequency during the delayed observation and/or the baseline. Original images in panel a) were adapted from vectorportal.com (MRI scanner; CC BY 4.0 license), svgrepo.com (earphones; CC0 license), and freesvg.org (ear; public domain).

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Fig 4 Expand

Table 3.

Time intervals between the baseline session and the delayed observations.

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Table 3 Expand