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Fig 1.

Directed acyclic graph.

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Fig 2.

Cohort derivation.

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Fig 3.

Covariate balance before and after overlap weighting.

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Fig 4.

Possible selection bias.

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Table 1.

The relative characteristics and outcomes of critically ill COVID-19 patients partitioned by nicotine dependence status.

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Table 2.

Overlap weighted means of COVID-19 hospitalizations for current and never nicotine dependent individuals.

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Table 3.

The association of nicotine dependence and mortality among critically-ill COVID-19 patients.

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Table 4.

Sensitivity analyses for the association of current versus never nicotine dependent and mortality among critically-ill COVID-19 patients.

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Table 5.

Sensitivity analyses by year for the association of nicotine dependence and mortality among critically-ill COVID-19 patients.

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Table 6.

Subgroup analyses for the association of nicotine dependence and in-hospital mortality among critically-ill COVID-19 patients.

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Table 7.

Subgroup analyses for the association of nicotine dependence and short-term mortality among critically-ill COVID-19 patients.

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Fig 5.

Forest plot for in-hospital mortality.

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