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Fig 1.

Schematic diagrams illustrating the two studied topographies.

(a) Squares design (symmetrical) and (b) Lines design (non-symmetrical).

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Fig 1 Expand

Fig 2.

Swelling-based topography fabrication process, (A) photoresist layer deposition and heating, (B) patterning the designs using direct laser photolithography and the development process, (C) washing the substrate with DI water and then immersing it into decane, (D) using isopropanol to remove the remaining photoresist.

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Fig 2 Expand

Fig 3.

SEM images showcasing the patterned surfaces.

(a) Squares with 30 μm dimensions, (b) Squares with 150 μm dimensions, (c) Lines with 30 μm length and spacing, and (d) Lines with 150 μm length and spacing.

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Fig 3 Expand

Fig 4.

Contact angles for a symmetrical design (squares).

Photographs depict DI droplets on the surface of different spacing and sizes (a). Contact angle measurements before and after plasma treatment (b).

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Fig 4 Expand

Fig 5.

Contact angles for a non-symmetrical design (lines).

Photographs depict DI droplets on the surface observed along two orientations: (a) along the lines and (b) perpendicular to the lines. Contact angle measurements before and after plasma treatment are taken along the lines (c) and perpendicular to the lines (d). The insets on top of parts a and b show the direction of measurement for the contact angle.

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Fig 5 Expand

Fig 6.

Temporal evolution of surface wettability for both symmetrical and non-symmetrical topographies.

(a) Rectangular topography was observed along the lines. (b) Square-shaped topography.

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Fig 6 Expand

Fig 7.

Candida biofilm formation on symmetrical and non-symmetrical topographies.

(a) 10 μm squares, (b) 30 μm squares, (c) 30 μm lines, and (d) 250 μm lines.

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Fig 7 Expand