Fig 1.
Trial profile.
Table 1.
Baseline characteristics of women by randomization method$ (mITT analysis).
Fig 2.
Total testosterone (nmol/L), SHBG (nmol/L) and free testosterone (nmol/L), outcomes at baseline and 25 weeks (mITT analysis).
Graphs indicate median with interquartile range (IQR). Significant differences were calculated by mixed effects linear regression, accounting for repeated measurements per participant and clustering by site and are indicated by asterisks where * and **** represent p<0.05 and p<0.0001, respectively.
Table 2.
Total testosterone (nmol/L), SHBG (nmol/L) and free testosterone (pmol/L) outcomes at baseline and 25 weeks (mITT analysis).
Table 3.
Mean percentage changes (95% CI) in total testosterone, SHBG and free testosterone (mITT analysis).
Table 4.
Pairwise comparisons of hormonal results for DMPA-IM vs NET-EN expressed as mean percentage differences (95% CI) (mITT analysis).