Fig 1.
Flowchart of the study population.
A total of 82 patients with PPROM were eligible for this study. Vaginal Ureaplasma was positive in 51 patients and negative in 31 patients. Of the patients who had positive vaginal Ureaplasma and completed the standard antibiotic regimen, 18 (75%) had increased vaginal Ureaplasma after treatment. Among patients with a positive vaginal Ureaplasma delivered before completion of all antibiotic doses, vaginal Ureaplasma increased in eight patients (40%). PPROM, preterm premature rupture of membranes; NEG, negative.
*intravenous 2 g ampicillin every 6 hours for 2 days, a single oral dose of 1 g azithromycin, and 5 days of oral 500 mg amoxicillin every 8 hours.
Table 1.
Maternal characteristics and perinatal findings, classified into three groups based on vaginal Ureaplasma changes by antibiotic treatment.
Fig 2.
The change of microbial load of vaginal Ureaplasma DNA before and after antibiotic regimen.
There were many cases of increased vaginal Ureaplasma, especially in patients who had completed the antibiotic regimen.
*intravenous ampicillin 2 g every 6 hours for 2 days and a single oral dose of azithromycin 1 g followed by 5 days of oral amoxicillin 500 mg every 8 hours.
Fig 3.
The change of microbial load of vaginal Lactobacillus spp.
DNA before and after antibiotic regimen. Almost all Lactobacillus spp. were decreased or disappeared after the antibiotic regimen, especially in the cases that completed the antibiotic regimen.
*intravenous 2 g ampicillin every 6 hours for 2 days, a single oral dose of 1 g azithromycin, and 5 days of oral 500 mg amoxicillin every 8 hours.
Table 2.
Changes of Ureaplasma, Mycoplasma hominis, and Lactobacillus spp. in completed antibiotic regimen group.
Table 3.
Changes of Ureaplasma, Mycoplasma hominis, and Lactobacillus spp. in uncompleted antibiotic regimen group.
Table 4.
The neonatal complications according to vaginal Ureaplasma changes due to the antibiotic regimen.