Table 1.
Definitions used when extracting data on each predictive factor for meta-analysis.
Fig 1.
Flowchart for eligible studies identification according to PRISMA 2020 guidelines.
PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses).
Table 2.
Characteristics of eligible studies.
Table 3.
Predictive factors for a diagnosis of coeliac disease, and the frequency in which they were reported in the included studies.
This table is restricted to factors reported in ≥5 studies and therefore eligible for inclusion in the meta-analysis. Some studies did not report sufficient data to allow for inclusion in meta-analysis, so the total studies figures included in this table maybe higher than the number of included studies for the corresponding meta-analysis.
Table 4.
Study quality and risk of bias assessment for all included studies, assessed using the Newcastle Ottawa Scale (NOS) for cohort studies or Case-Control (C-C) studies, the modified NOS for Cross-Sectional (C-S) studies, or the Risk of Bias 2 (RoB 2) Tool for Randomized Trials.
Fig 2.
Summary forest plot for predictive factors included in meta-analysis.
Upper region of plot displays pooled odds ratio estimates and lower region of plot displays standardized mean difference.
Table 5.
Sensitivity analysis of meta-analysis for each predictive factor comparing Hartung-Knapp-Sidik-Jonkman (HKSJ) and DerSimonian and Laird (DL) odds ratio (OR) estimates or standardized mean difference (SMD) and if they were significant for each predictive factor.
Significance assessed as p≤0.05.