Table 1.
Formula used for the preparation of simple ointment [25].
Fig 1.
Photograph of excision wound healing progress after treated with the hydrometanolic extract of the C. myricoides.
Table 2.
Wound healing activity of extract of the leaves of Clerodendrum myricoideson excision wound model in mice.
Table 3.
Wound healing activity of solvent fractions of the leaves of Clerodendrum myricoides on excision wound model in mice.
Fig 2.
Effect of extract on period of epithelialization in excision wound.
(A) = period of epithelialization, (B) = Percentage reduction in the period of epithelialization. Values are expressed as mean ± SEM (n = 6)and one-way ANOVA followed by post hoc Tukey’s test were used for analysis. a Compared to simple ointment, b compared to 5% CEO, 1p<0.05, 3p<0.001, percent reduction in period of epithelialization is from the SO treated group. Where CEO: crude extract ointment; NFO: nitrofurazone ointment.
Table 4.
Wound healing activity of extract of the leaves of Clerodendrum myricoides solvent fraction on period of epithelialization.
Fig 3.
Images of histological sections of excision wound tissue.
Notes: (A): histological section of wound tissue from simple ointment, (B): histological section of wound tissue of 5% extract treated mouse, (C): histological section of wound from 10% extract treated mouse, (D): histological section of wound from nitrofurazone 0.2% treated mouse.
Table 5.
Effect of the leaves of Clerodendrum myricoides hydroalcoholic extract on the excision wound histology of skin of mice.
Fig 4.
Note: (A): on the day of wound creation, (B): measuring tensile strength by water flow method, (C): broken skin by water flow technique.
Table 6.
Wound healing activity of extract of the leaves of Clerodendrum myricoides on tensile strength of incision wound model.
Fig 5.
Photograph of burn wound healing progress after treated with the hydrometanolic extract of the C. myricoides.
Table 7.
Wound healing activity of extract of the leaves of Clerodendrum myricoides on burn wound model in mice.
Fig 6.
Effect of extract on period of epithelialization in burn wound.
(A) = period of epithelialization, (B) = Percentage reduction in the period of epithelialization. Values are expressed as mean ± SEM (n = 6)and one-way ANOVA followed by post hoc Tukey’s test were used for analysis. aCompared to simple ointment, bcompared to 5% extract, 1p<0.05, 3p<0.001, percent reduction in period of epithelialization is from the simple ointment treated group.
Fig 7.
Images of histological sections of burn wound tissue.
Notes: (A): histological section of wound tissue from simple ointment, (B): histological section of wound tissue of 5% extract treated mouse, (C): histological section of wound from 10% extract treated mouse, (D): histological section of wound from nitrofurazone 0.2% treated mouse.
Table 8.
Effect of the leaves of Clerodendrum myricoides hydroalcoholic extract on the burn wound histology of skin of mice.
Fig 8.
Percent of inflammation inhibition of extract of the leaves of Clerodendrum myricoides on carrageenan-induced mice paws edema.
Table 9.
Anti-inflammatory activity of extract of the leaves of Clerodendrum myricoideson carrageenan-induced mice paws edema.