Fig 1.
RSiCC Study Framework adapted from NIH-SSM.
The study framework combines injury characteristics, medical and psychosocial histories, patient reported outcome surveys, and biologic signatures to develop a model to stratify risk for prolonged PCS in pediatric concussion.
Table 1.
Inflammatory genetic variants involved in brain injury and in fatigue.
Table 2.
Inflammatory cytokines, actions specific to the brain, and associated PCS.
Fig 2.
Potential PCS trajectory typologies.
Children might have a high number of PCS early on that either resolve (recovered) or persist (chronic). Or they might have a low number of PCS early on and either remain relatively asymptomatic (resilient) or develop additional PCS over time (delayed). Adapted from Galatzer-Levy et al., 2018.
Table 3.
Data-collection constructs, measures, and administration.