Fig 1.
Abbreviations: MRI = Magnetic Resonance imaging.
Fig 2.
Univariate correlations between serum ferritin, magnetic resonance imaging (MRI), and bone biopsy parameters.
A. Serum ferritin and Liver R2*Water. B. Serum ferritin and right iliac crest R2*Water. C. Right iliac crest R2*Water and number of Fe+ bone marrow cells adjusted by bone marrow area. D. Right iliac crest R2*Water and liver R2*Water.
Table 1.
Laboratory parameters and bone mineral density before and after 12 months after DFO.
Fig 3.
Illustrative MRI of a given patient at baseline and at the end of follow-up.
The figure shows R2*Water maps (R2*Water) overlap in the axial images of the upper abdomen and pelvis before (A and B) and after (C and D) treatment. The liver R2*Water showed a median value of 207 s-1 in A and 81 s-1 in C after treatment, which correlated with the reduction in serum ferritin levels. The same can be observed in the spleen, from 373 s-1 in A to 258 s-1 in C. The bones also demonstrated a reduction in the R2*Water values, ranging from 148 s-1 to 94 s-1 for the L3 vertebra (A and C) and from 151 s-1 to 95 s-1 (B and D) in the left iliac crest. Republished from Body Digital Pte Ltd under a CC BY license, with permission from Wanida Chua-anusorn, original copyright 2024.
Table 2.
Magnetic resonance imaging (MRI) of liver, heart, lumbar spine, and iliac crest at baseline and at the end of follow-up.
Fig 4.
Liver R2*Water (A) and right iliac crest R2*Water (B) MRI parameter pre- and post-treatment.
Fig 5.
Turnover, Mineralization, and Volume (TMV) classification at the different timepoints.
TMV distribution and individual evolution at baseline and at the 12-month follow-up.
Table 3.
Bone histomorphometry at baseline and at the end of follow-up.
Table 4.
Turnover, Mineralization, and Volume (TMV) classification at baseline and 12 months after treatment with DFO.