Fig 1.
Distribution of baseline characteristics and ventilatory variables between the weaning success group and the weaning failure group.
(A) Age. (B) Body mass index (BMI). (C) SOFA score. (D) Respiratory rate (RR). (E) Tidal volume (VT). (F) Plateau pressure (Pplat). (G) Dynamic lung compliance (Cdyn). (H) Mechanical power (MP). (I) MP normalized to Cdyn (Cdyn-MP). The area shaded with red shows the density map of the frequency distribution of weaning success group, and blue represents the weaning failure group. In the depicted figure, the weaning failure group exhibited higher values for the BMI, SOFA score, RR, Pplat, Cdyn, MP, and Cdyn-MP, as compared to the weaning success group.
Table 1.
Clinical characteristics of the study population according to mechanical power normalized to dynamic lung compliance (Cdyn-MP).
Fig 2.
Weaning failure incidence as expressed in MP normalized to dynamic lung compliance (Cdyn-MP) quartile.
Q1, Q2, Q3, and Q4 are quartiles of the Cdyn-MP. Corresponding quartile cut-off values are shown in Table 1. Different letters represent significant differences between different groups (P<0.05).
Table 2.
Multivariable-adjust odds ratio and 95% confidence interval of the Cdyn-MP quartiles associated with weaning failure.
Fig 3.
Association between mechanical power normalized to dynamic lung compliance (Cdyn-MP) and weaning failure.
Solid lines represent the best-fit curve, and dashed lines represent a 95% confidence interval. Odd ratios (ORs) were adjusted for age, body mass index, SOFA score, respiratory rate, positive end-expiratory pressure, plateau pressure, FiO2, white blood cell count, serum creatinine, Uorate, heart rate, mean blood pressure and SpO2. The blue histograms represent the frequency distribution for weaning failure among mechanically ventilated patients. Only 99% of the data are shown.
Fig 4.
Subgroup analyses of the mechanical power normalized to dynamic lung compliance (Cdyn-MP) and weaning failure.
Each stratification was adjusted for age, body mass index (BMI), SOFA score, respiratory rate, positive end-expiratory pressure, plateau pressure, FiO2, white blood cell count, serum creatinine, Uorate, heart rate, mean blood pressure and SpO2 except the stratification factor itself. Diamonds indicate overall odds ratios (ORs), with outer points of the diamonds. indicating 95% CIs. Squares indicate ORs, with horizontal lines indicating 95% confidence intervals. IMV, invasive mechanical ventilation; COPD, chronic obstructive pulmonary disease.