Table 1.
Overview of official gene symbol, gene name, and alias used in the text.
Fig 1.
Intracellular uric acid concentrations in HUVEC treated with allopurinol and febuxostat compared with matched control condition.
(A) effect of febuxostat in combination with 100μM uric acid on intracellular uric acid concentrations; (B) effect of febuxostat in combination with 350μM uric acid on intracellular uric acid concentrations; (C) effect of allopurinol in combination with 100μM uric acid on intracellular uric acid concentrations; (D) effect of allopurinol in combination with 350μM uric acid on intracellular uric acid concentrations; Hashtags represent P-values calculated with Friedman’s test, ##P<0.01, ###P<0.001; Asterixis represent P-values calculated with Dunn’s test, **P<0.01; Box represents median, 25th, and 75th percentile, whiskers represent range.
Fig 2.
Comparison of mRNA expression of uric acid transporters in HUVEC and HAEC calculated with the Livak method.
*P<0.05, **P<0.01; Each bar represent mean ±SD.
Fig 3.
mRNA expression of uric acid transporters in HUVEC treated with allopurinol and febuxostat compared with matched control condition.
(A) effect of febuxostat in combination with uric acid on MRP4 mRNA expression; (B) effect of febuxostat in combination with uric acid on GLUT9 mRNA expression; (C) effect of febuxostat in combination with uric acid on BCRP mRNA expression; (D) effect of allopurinol in combination with uric acid on MRP4 mRNA expression; (E) effect of allopurinol in combination with uric acid on GLUT9 mRNA expression; (F) effect of allopurinol in combination with uric acid on BCRP mRNA expression; Hashtags represent P-values calculated with Friedman’s test, #P<0.05; Asterixis represent P-values calculated with Dunn’s test, *P<0.05; Box represents median, 25th, and 75th percentile, whiskers represent range.
Fig 4.
Cell count in HUVEC treated with allopurinol and febuxostat compared with matched control condition.
(A) effect of febuxostat in combination with 100μM uric acid on cell count; (B) effect of febuxostat in combination with 350μM uric acid on cell count; (C) effect of allopurinol in combination with 100μM uric acid on cell count; (D) effect of allopurinol in combination with 350μM uric acid on cell count; Box represents median, 25th, and 75th percentile, whiskers represent range.