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Fig 1.

PRISMA flow diagram of the study selection criteria.

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Fig 1 Expand

Fig 2.

Overview of seven non-surgical methods combined with mechanical debridement in the treatment of peri-implant diseases.

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Table 1.

Summary table of meta-analyses comparing clinical efficacy of different non-surgical therapy combined with mechanical debridement in treatment of peri-implantitis.

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Table 1 Expand

Table 2.

Summary table of meta-analyses comparing clinical efficacy of different non-surgical therapy combined with mechanical debridement in treatment of peri-implant mucositis.

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Table 2 Expand

Fig 3.

Risk of bias graph of the included studies.

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Fig 3 Expand

Fig 4.

Network diagram for effect of each treatment.

(A) PPD reduction for PI, (B) PPD reduction for PM, (C) BoP reduction for PM, (D) PLI reduction for PM, (E) CAL changes for PI, and (F) MBL changes for PI.

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Fig 4 Expand

Fig 5.

Ranking probability of each treatment.

(A) PPD reduction for PI, (B) PPD reduction for PM, (C) BoP reduction for PM, (D) PLI reduction for PM, (E) CAL changes for PI, and (F) MBL changes for PI. Label: MD = A MD+ Laser = B MD+PBMT = C MD+PDT = D MD+SA = E MD+ probiotics = F MD+LA = G MD+APP = H.

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Fig 5 Expand

Table 3.

Standardized mean differences (SMDs) and 95% CI on PPD reduction of PI.

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Table 3 Expand

Table 4.

Standardized mean differences (SMDs) and 95% CI on PPD reduction of PM.

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Table 4 Expand

Table 5.

Standardized mean differences (SMDs) and 95% CI on BoP reduction of PM.

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Table 5 Expand

Table 6.

Standardized mean differences (SMDs) and 95% CI on PLI reduction of PM.

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Table 6 Expand

Table 7.

Standardized mean differences (SMDs) and 95% CI on CAL reduction of PI.

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Table 7 Expand

Table 8.

Standardized mean differences (SMDs) and 95% CI on MBL reduction of PI.

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Table 8 Expand

Fig 6.

Funnel plot on publication bias.

(A) PPD reduction for PI, (B) PPD reduction for PM, (C) BoP reduction for PM, (D) PLI reduction for PM, (E) CAL changes for PI, and (F) MBL changes for PI. Label: MD = A MD+ Laser = B MD+PBMT = C MD+PDT = D MD+SA = E MD+ probiotics = F MD+LA = G MD+APP = H.

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Fig 6 Expand