Fig 1.
PRISMA flow diagram.
Table 1.
Proportion meta-analyses of the distribution of vaccine serotypes by condition in LAC, by five-year period, age groups, and countries.
Fig 2.
Meta-analysis of incidence of all invasive pneumococcal disease by age groups.
Table 2.
Case fatality rate according to type of IPD and sub- analysis by 5-year period, age and country.
Fig 3.
Interrupted time series of S. pneumoniae isolates before and after PCV13 and PCV10 introduction in Argentina, Brazil, Chile, and Colombia from 2006 to 2018.
The red dotted line indicates the year of introduction of the vaccines.
Fig 4.
Interrupted time series of the percentage of S. pneumoniae serotypes in passive surveillance included in PCV10 and PCV13 in Argentina, Brazil, Chile, and Colombia between 2006 and 2018 and the percentage of PCV20 serotypes (orange dotted line) between 2013 and 2018.
The red dotted line indicates the year of introduction of the vaccines.