Fig 1.
Abomasal pH of study ewes (n = 4) on day 0, as well as days 1–3 post pantoprazole (1 mg/kg) administration via the intravenous (IV: Orange) or subcutaneous (SC: Grey) routes.
Asterisk (*) indicates statistically significant (P < 0.05) difference from pre-pantoprazole administration baseline. Dashed line represents a pH of 4.0.
Table 1.
Abomasal pH values during various timepoints after administration of 1.0 mg/kg of pantoprazole intravenously once daily for 3 administrations in adult ewes.
Hours 0–18 correspond to pre-administration baseline, and hours 24–42; 48–66; and 72–90 correspond to the first, second and third administrations respectfully.
Table 2.
Abomasal pH values during various timepoints after administration of 1.0 mg/kg of pantoprazole subcutaneously once daily for 3 administrations in adult ewes.
Hours 0–18 correspond to pre-administration baseline, and hours 24–42; 48–66; and 72–90 correspond to the first, second and third administrations respectfully.
Fig 2.
Time vs concentration curve for pantoprazole after intravenous (orange diamond) and subcutaneous (grey square) administration of 1.0 mg/kg to adult ewes.
Upward bars represent error.
Fig 3.
Time vs concentration curve for pantoprazole sulfone after intravenous (orange diamond) and subcutaneous (grey square) administration of 1.0 mg/kg pantoprazole sodium to adult ewes.
Upward bars represent error.
Table 3.
Pharmacokinetic parameters of pantoprazole after single dose intravenous (IV; 1 mg/kg) and subcutaneous (SC; 1 mg/kg) administration in sheep (n = 4).
Table 4.
Pharmacokinetic parameters of pantoprazole sulfone after single dose intravenous (IV) and subcutaneous (SC) administration of pantoprazole sodium (1.0 mg/kg) in sheep (n = 4).
Table 5.
Comparative pantoprazole pharmacokinetic values currently reported in the veterinary literature.