Table 1.
Number of samples used in the association test from 12 countries (duration / age) with interquartile range and median.
Fig 1.
Histograms for phenotypes duration before (A) and after (B) Box-Cox transformation and age before (C) and after (D) Box-Cox transformation.
Fig 2.
Quantile-Quantile plots for phenotypes duration before (A) and after (B) Box-Cox transformation and age before (C) and after (D) Box-Cox transformation.
Fig 3.
Quantile-Quantile plot with duration as phenotype.
Fig 4.
Quantile-Quantile plot with age as phenotype.
Fig 5.
Manhattan plot with clinical duration as phenotype.
(red line indicating genome-wide significance of 5x10-8; blue line indicating suggestive genome-wide significance (5x10-8 > pvalue < 1x10-5)).
Fig 6.
Regional association plot at PRNP locus with clinical duration as phenotype (additive model).
Fig 7.
Regional association plot at PRNP locus with clinical duration as phenotype (heterozygous model).
Fig 8.
Regional association plot at PRNP locus for conditional analysis on SNP rs1799990 with clinical duration as phenotype (additive model).
Table 2.
Top 10 genes identified by MAGMA (standalone) gene analysis (including genome-wide significant SNPs) with duration as phenotype.
Table 3.
Top 10 genes identified by FUMA gene analysis (including genome-wide significant SNPs) with duration as phenotype.
Fig 9.
Manhattan plot with age at onset as phenotype.
(red line indicating genome-wide significance of 5x10-8; blue line indicating suggestive genome-wide significance (5x10-8 > pvalue < 1x10-).
Table 4.
Top 10 pathways identified by MAGMA (standalone) gene-set analysis (including genome-wide SNPs) using duration as phenotype.
Table 5.
Top 10 pathways identified by FUMA gene-set analysis (including genome-wide SNPs) using duration as phenotype.