Fig 1.
Study flow chart.
Table 1.
Study and population characteristics of the included studies.
Fig 2.
QUADAS-2 assessment summary graph ‐ Review authors’ judgements.
Table 2.
QUADAS-2 quality assessment summary ‐ Review authors’ judgements.
Table 3.
Pooled estimates for each strategy.
Fig 3.
Summary plots for ADD-RS and ADD-RS in combination with D-Dimer.
The summary plots for ADD-RS alone are presented in panel A and B, and the summary plots for ADD-RS with D-Dimer are presented in panel C and D. Individual sensitivity and specificity from the same study are linked with lines. In panel A and C, receiver operating characteristic (ROC) plots are displayed. In panel B and D, pooled sensitivity and specificity along with the 95% credible intervals and 95% prediction intervals are plotted. The 95% credible intervals are marked by the shaded areas around the summary estimates, showing the range of likely values for average diagnostic accuracy. The 95% prediction intervals are marked by the wider and lighter shaded areas around the summary estimates, indicating a range of values that might be expected in a future study.
Fig 4.
Summary plot for Canadian guideline.
Blue circles indicate individual studies scaled with the sample size.
Fig 5.
Pooled estimates and 95% credible intervals for each strategy.