Fig 1.
A detailed description of study design.
MR, Mendelian randomization; GERD, gastroesophageal reflux disease; TSMR, Two-sample Mendelian randomization; MVMR, multivariable Mendelian randomization; MMR, mediation Mendelian randomization; IVW, inverse variance weighting; MR-Egger, MR-Egger regression; MR-PRESSO, MR Pleiotropy RESidual Sum and Outlier test; MR-RAPS, MR robust adjusted profile score.
Table 1.
Phenotypic details of this study.
Fig 2.
Two-sample Mendelian randomization analysis causal estimation.
NSNP, number of SNPs; OR, odds ratio; 95% CI, 95% confidence interval; GERD, gastroesophageal reflux disease; IVW, inverse variance weighting; MR-Egger, MR-Egger regression; MR-PRESSO, MR Pleiotropy RESidual Sum and Outlier test; MR-RAPS, MR robust adjusted profile score.
Fig 3.
Scatterplots for the results of the two-sample Mendelian randomization analysis.
GERD, gastroesophageal reflux disease; MR, Mendelian randomization; SNP, single nucleotide polymorphism.
Fig 4.
MVMR analysis causal estimation.
NSNP, number of SNPs; OR, odds ratio; 95% CI, 95% confidence interval; IVW, inverse variance weighting; CigDay, cigarettes per day; DrnkWk, alcoholic drinks per week; BMI, body mass index; T2D, type 2 diabetes.
Table 2.
Heterogeneity and pleiotropy of MR analysis.
Table 3.
Mediation effect of depression on the GERD to migraine.