Fig 1.
Flow diagram of patient selection.
NAFLD- nonalcoholic fatty liver disease, VCTE- vibration controlled transient elastography, CAP- controlled attenuation parameter, FAST- FibroScan-AST score.
Table 1.
Baseline characteristics of the patients included in the study.
Fig 2.
LSM-VCTE, Agile 3+ and Agile 4 scores among 246 patients with biopsy-proven NAFLD.
Median values (lines inside boxes) for (a) LSM-VCTE, (b) Agile 3+, (c) Agile 4 are shown in the box graph, together with the 25th–75th percentiles, respectively. LSM–liver stiffness measurement, VCTE–vibration controlled transient elastography, kPa–kilopascals, NASH–nonalcoholic steatohepatitis, CRN–Clinical Research network, F0 –absence of fibrosis, F1 –mild fibrosis, F2 –significant fibrosis, F3 –advanced fibrosis, F4 –cirrhosis.
Fig 3.
Diagnostic performance of Agile 3+, Agile 4, LSM-VCTE and FIB-4 in identifying advanced fibrosis (≥F3).
ROC—receiver operating characteristic curve, VCTE–vibration-controlled transient elastography, FIB-4 –Fibrosis 4 Index, kPa–kilopascals.
Table 2.
Diagnostic accuracy of Agile 3+, Agile 4, LSM -VCTE and FIB-4 in identifying advanced fibrosis (≥F3) among 246 patients with biopsy-proven NAFLD.
Fig 4.
Diagnostic performance of Agile 3+, Agile 4, LSM-VCTE and FIB-4 in identifying cirrhosis (F4) among 246 patients with biopsy-proven NAFLD.
ROC—receiver operating characteristic curve, VCTE–vibration-controlled transient elastography, FIB-4 –Fibrosis 4 Index, kPa–kilopascals.
Table 3.
Diagnostic accuracy of Agile 3+, Agile 4, LSM-VCTE and FIB-4 in identifying cirrhosis (F4) among 246 patients with biopsy-proven NAFLD.
Table 4.
Comparison between Agile 3+, Agile 4, and standard NITs in staging liver fibrosis using DeLong protocol.
Table 5.
Distribution of patients with biopsy-proven NAFLD according to the individual risk.
Fig 5.
Diagnostic performance of FAST score and other NITs in predicting fibrotic NASH.
ROC—receiver operating characteristic curve, FAST- FibroScan-AST score, VCTE–vibration-controlled transient elastography, FIB-4 –Fibrosis 4 Index, APRI—aspartate aminotransferase to platelet ratio index.
Table 6.
Diagnostic accuracy of FAST score in predicting fibrotic NASH (NASH + NAS≥4 + F≥2).